Japanese researchers discover new antiseptic agent to fight periodontitis

0 23 October 2014

TOKYO, Japan: The results of a recently published study have shown that ozone nano-bubble water (NBW3) is very effective against two bacteria that cause periodontitis. The researchers believe that this new antimicrobial agent could be used in the development of new therapies for the inflammatory disease, which affects 15 to 20 per cent of middle-aged adults in its severest form worldwide. In in vitro experiments, researchers at Tokyo Medical and Dental University and the National Institute of Advanced Industrial Science and Technology in Japan tested the effectiveness of NBW3 against Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. They found that the levels of both bacteria dropped to below the lower limit of detection after only 30 seconds of exposure. In addition, they observed that NBW3 had no significant impact on human oral tissue. Using an in vitro human oral tissue model, composed of human-derived epithelial cells, they found only minor decreases in the viability of cells after 24 hours of exposure. Such models are used to test the toxicity and irritation potential of new dental materials and oral care products. According to the researchers, they are more predictive of human responses and more clinically relevant than are animal and monolayer cell culture test systems. Conventional antibiotic therapies for treating periodontitis hold the risk of sever