October 23, 2014

AUSTIN, Texas, USA: Studies on the human microbiome have shown that shifts in oral microbiota are associated with a number of diseases, including obesity, Crohn’s disease, diabetes and periodontitis. Now, U.S. scientists have found that oral bacteria act differently in diseased patients compared with healthy individuals. They believe that the findings could be used to develop methods to prevent or even reverse diseases such as periodontal disease. Although it is known that the composition of the microbiome changes during the transition from health to disease, it is still unclear how specific activities of different members of the microbial community affect diseases. In order to understand how different bacteria act in healthy and diseased individuals, researchers at the University of Texas at Austin examined periodontal plaque samples from ten patients from Izmir in Turkey with aggressive periodontitis. Using supercomputers, the researchers compared the expression of 160,000 genes in healthy and diseased periodontal communities and found that these communities show defined differences in metabolism. “In other words, a species of bacteria that ate one thing, such as fructose, can switch to a different kind of sugar to feed on if diseased,” explained Dr. Marvin Whiteley, professor of molecular biosciences at the university. A major question concerning the mechanism underlying the changes is whether changes in composition and behavior cause diseases or are a consequence of diseases. In this respect, the present study demonstrated that differential expression of metabolic genes was associated with the periodontal disease state. For instance, the expression of butyrate production genes by the bacterium Fusobacterium nucleatum increased during disease, suggesting that F. nucleatum butyrate production promotes periodontitis. However, further studies are needed to verify this hypothesis, the researchers said. Whiteley said that the research could help determine biomarkers that predict whether a patient is at risk of developing periodontitis. As bacterial populations can be manipulated, researchers might be able to shift them back to that of a healthy microbiome . The findings may thus also benefit periodontal treatment. According to the latest figures provided by the Centers for Disease Control and Prevention, about 47 percent of adults aged 30 and over in the U.S. have periodontitis. The organization estimates that over 8 percent of adults have severe periodontitis. The study, titled “Metatranscriptomics of the Human Oral Microbiome during Health and Disease,” was published in the April issue of mBio, an open-access journal published by the American Society for Microbiology.

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October 23, 2014

TOKYO, Japan: The results of a recently published study have shown that ozone nano-bubble water (NBW3) is very effective against two bacteria that cause periodontitis. The researchers believe that this new antimicrobial agent could be used in the development of new therapies for the inflammatory disease, which affects 15 to 20 per cent of middle-aged adults in its severest form worldwide. In in vitro experiments, researchers at Tokyo Medical and Dental University and the National Institute of Advanced Industrial Science and Technology in Japan tested the effectiveness of NBW3 against Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. They found that the levels of both bacteria dropped to below the lower limit of detection after only 30 seconds of exposure. In addition, they observed that NBW3 had no significant impact on human oral tissue. Using an in vitro human oral tissue model, composed of human-derived epithelial cells, they found only minor decreases in the viability of cells after 24 hours of exposure. Such models are used to test the toxicity and irritation potential of new dental materials and oral care products. According to the researchers, they are more predictive of human responses and more clinically relevant than are animal and monolayer cell culture test systems. Conventional antibiotic therapies for treating periodontitis hold the risk of several side-effects, such as the development of bacterial resistance and adverse host reactions. However, NBW3 is produced from ozone, which has strong antimicrobial activity against bacteria, fungi and viruses, and thus does not induce antimicrobial resistance. Ozonated water usually retains its potency for only a short period, but NBW3, which the researchers produced using a patented technique, retains its oxidation ability for more than six months. This stability allows for the bottling and use of NBW3 as a disinfectant. Although the results of the present study are promising, these in vitro models cannot be directly translated into clinical situations, in which NBW3’s potency may be reduced by dental patients’ saliva. Therefore, further research is needed. The study, titled “Effects of ozone nano-bubble water on periodontopathic bacteria and oral cells – In vitro studies”, was published in the September issue of the Science and Technology of Advanced Materials journal.

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October 20, 2014

Dental implant surgical placement means placement of foreign bodies in the oral region, in order to provide better and more successful prosthetic rehabilitation. To date, the implants used extensively as a variety of materials with more or less success, since it is the body sooner or later rejected. How does dental implant looks like? Based on current knowledge, it can be said that metals such as stainless steel, chromium-cobalt-molybdenum alloys, precious metals and many polymers, bone tissue can be tolerated but not integrated. However, titanium, tantalum, niobium and others, like aluminum oxide ceramics, which are described as almost bioinert may be osteointegrated under certain conditions.

Our clinic Eurodent in Belgrade, Serbia, guarantee the safe and secure implant surgery, will provide you a more beautiful smile and allow you to save money, because of our affordable services at low cost implants.

You can see it on presented picture how does it looks like:

 

Dental implant

tooth/dental implant

adding crown to dental implant

Dental implant in jaw

Dental implant in jaw

adding crown to dental implant

Implants that are widely used can be metallic or non-metallic origin. In manner and place of incorporation, as commonly applied so far mentioned subperiostal and intraosal (enosal) implants. Subperiostal are very much applied the sixties and seventies, to the development and application of new generation enosal implants were almost completely rejected.Enosal implants can be of different shapes: needle, plate (exfoliated), cylindrical, in the form of a variety of fasteners (screws) and others. Different in size and may be one or two piece, and of various lengths. Conventional (classical) dental prosthetics, along with preprotetic surgery, has certain limits and possibilities. Many patients from the psychological, aesthetic and functional reasons for wanting to wear the crowns, even though their local status, it does not allow. Many of them also believe that they crowns provide better quality of life. Development of such compensation in such cases is possible only after the installation of implants. Although today almost came more common, many of the problems that arise after the installation is not fully resolved, for example. establishment of epithelial insertion at the point of passing imlant through the oral mucosa, and others.Regardless of the type applied enosal implants, there are certain indications for their use:
– Total edentulism of upper and lower jaws;
– Shortened dental arch, bilaterally or unilaterally;
– Inserted crowns;
– Lack of a (usually) the front teeth.

Contraindications for implants can be:

General – chronic systemic disease (diabetes, liver cirrhosis, rheumatic and neurovascular diseases, etc.);

Local – adverse hygiene index, a very pronounced atrophy of alveolar bone, periodontium insufficient, an unfavorable schedule and location of remaining teeth.
It should be noted that the marked atrophy relative contraindication, as perfected in recent years and developed a combined method of simultaneous osteoplastic bone loss and implantation of cylindrical implants enosal.
Before proceeding to the act of implantation is necessary to do some preliminary work:
– A detailed personal history and routine laboratory analysis;

– Radiograph;

– Clinical and radiographic assessment of the condition of existing teeth and jaw bones;

– Preparation of study models;

– Determining the possible advantages or disadvantages of prosthetic rehabilitation using implants.